{"product_id":"9783319825281","title":"Resistance to Targeted Anti-Cancer Therapeutics","description":"\u003ch1\u003eResistance to Targeted Anti-Cancer Therapeutics\u003c\/h1\u003e \u003ch2\u003eDonnadieu, Emmanuel\u003c\/h2\u003e \u003cp\u003eThis volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.\u003c\/p\u003e\u003cdiv\u003eThe volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.\u003c\/div\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2018-04-22\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319825281\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-42223-7\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 199\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":44395441520780,"sku":"9783319825281","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319825281.jpg?v=1770822027","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783319825281","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}