{"product_id":"9783319817156","title":"Advances in Experimental Medicine and Biology","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology\u003c\/h1\u003e \u003ch2\u003eMoraes, Isabel\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects.  Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. \u003c\/p\u003e  This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes:\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eExpression screening using fluorescent proteins\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe use of detergents in membrane protein research\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe use of NMR\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSynchrotron developments in membrane protein structural biology\u003c\/li\u003e\n\u003cli\u003eVisualisation and X-ray data collection of microcrystals\u003c\/li\u003e\n\u003cli\u003eX-ray diffraction data analysis from multiple crystals\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSerial millisecond crystallography\u003c\/li\u003e\n\u003cli\u003eSerial femtosecond crystallography\u003c\/li\u003e\n\u003cli\u003eMembrane protein structures in drug discovery\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003c\/p\u003e  \u003cp\u003eThe information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work.\u003c\/p\u003e\u003cp\u003eChapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2018-05-04\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319817156\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-35072-1\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 184\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":47979645960332,"sku":"9783319817156","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319817156.jpg?v=1777375572","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783319817156","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}