{"product_id":"9783319807089","title":"Lecture Notes in Computational Science and Engineering","description":"\u003ch1\u003eLecture Notes in Computational Science and Engineering\u003c\/h1\u003e \u003ch2\u003eTveito, Aslak; Lines, Glenn T.\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eFlow of ions through voltage gated\nchannels can be represented theoretically using stochastic differential\nequations where the gating mechanism is represented by a Markov model. The flow through a\nchannel can be manipulated using various drugs, and the effect of a given drug\ncan be reflected by\nchanging the Markov model. These lecture notes provide an accessible\nintroduction to the mathematical methods needed to deal with these models. They emphasize the use of\nnumerical methods and provide sufficient details for the reader to implement\nthe models and thereby study the effect of various drugs.  Examples in the\ntext include stochastic calcium release from internal storage systems in cells,\nas well as stochastic\nmodels of the transmembrane potential. Well known Markov models are studied and\na systematic approach to\nincluding the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties\nof a theoretical model of a drug for a given mutation defined in terms\nof a Markov model.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2018-04-22\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319807089\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-30030-6\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 261\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":46541375996044,"sku":"9783319807089","price":53.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319807089.jpg?v=1779505977","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783319807089","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}