{"product_id":"9783319804538","title":"Springer Theses: Micro- and Nano-scale Assessments","description":"\u003ch1\u003eSpringer Theses: Micro- and Nano-scale Assessments\u003c\/h1\u003e \u003ch2\u003eHazel, Garvie-Cook\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis work represents an inventive attempt to apply recent advances in \nnanotechnology to identify and characterise novel polymer systems for \ndrug delivery through the skin. Atomic\n force microscopy (AFM) measurements of the nanoscale mechanical \nproperties of topical, drug-containing polymeric films enabled the \nauthor to identify optimal compositions, in terms of flexibility and \nsubstantivity, for application to the skin. To elucidate\n the enhanced drug release from polyacrylate films incorporating medium \nchain triglycerides, the author combined AFM studies with the \ncomplementary technique of Raman micro-spectroscopy. This experimental \nstrategy revealed that the significant increase in the\n drug released from these films is the result of a nanoscale two-phase \nstructure. Finally, in experiments examining the microporation of skin \nusing femtosecond laser ablation, the author demonstrated that the \nthreshold at which the skin's barrier function\n is undermined can be dramatically reduced by the pre-application of \nink. The approach allows thermal damage at the pore edge to be \nminimised, suggesting a very real potential for substantially increasing\n drug delivery in a minimally invasive fashion.\n\u003c\/p\u003e\n\u003cb\u003e\u003c\/b\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2018-03-30\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319804538\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-28901-4\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 114\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":47393717026956,"sku":"9783319804538","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319804538.jpg?v=1775769904","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783319804538","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}