{"product_id":"9783319796727","title":"Regulation of Membrane Na+-K+ ATPase","description":"\u003ch1\u003eRegulation of Membrane Na+-K+ ATPase\u003c\/h1\u003e \u003ch2\u003eChakraborti, Sajal; Dhalla, Naranjan S\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eNa\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase is either mediated by changes in intracellular Na\u003csup\u003e+\u003c\/sup\u003e concentrations that directly affect the Na\u003csup\u003e+\u003c\/sup\u003e-pump activity or by phosphorylation\/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na\u003csup\u003e+\u003c\/sup\u003e-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra\u003c\/p\u003ene domain adjacent to the isoform(s) of α-β subunits of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+ \u003c\/sup\u003eATPase. Considering the extraordinary importance of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+\u003c\/sup\u003e ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled \u003ci\u003e“Regulation of Membrane Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+\u003c\/sup\u003e ATPase”\u003c\/i\u003e for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na\u003csup\u003e+\u003c\/sup\u003e-K\u003csup\u003e+\u003c\/sup\u003e ATPase regulation in health and disease.\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2019-03-27\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319796727\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-24750-2\u003c\/p\u003e \u003cp\u003eDimensions: 235.0cm x155.0cm\u003c\/p\u003e \u003cp\u003ePages: 436.0\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":44398673428620,"sku":"9783319796727","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319796727.jpg?v=1765484310","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783319796727","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}