{"product_id":"9783319422244","title":"Rolling Circle Amplification (RCA) Toward New Clinical Diagnostics and Therapeutics","description":"\u003ch1\u003eRolling Circle Amplification (RCA)\u003c\/h1\u003e\u003ch2\u003eToward New Clinical Diagnostics and Therapeutics\u003c\/h2\u003e\u003ch3\u003eVadim V. Demidov\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Biochemistry\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cdiv\u003eThis book covers the latest developments in rolling circle  amplification (RCA) technology with applications in clinical diagnostic  tests and molecular medicine. Topics covered include new enzymes useful  in RCA, techniques involving RCA for enhanced signal amplification,  novel RCA diagnostics, sensors for expediting RCA detection, and  prospective RCA-based therapeutics. This is a valuable book for  university professors and students in the field of biomedical  engineering and biomolecular pharmacology as well as R\u0026amp;D managers of  biotechnology and biopharmaceutical companies.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003eSpecifically, this book:\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003e\u003cul\u003e\n\u003cli\u003eReviews prospective RCA-based therapeutics, including RCA-derived DNA nanoparticles that strongly bind to cancer cells\u003c\/li\u003e\n\u003cli\u003eExpands  readers’ understanding of sensor systems for expediting detection of  RCA products by using probe-tagged magnetic nanobeads\u003c\/li\u003e\n\u003cli\u003eMaximizes reader insights into novel RCA diagnostics,such as PNA openers-assisted RCA for detection of single target cells and \u003ci\u003ein situ\u003c\/i\u003e RCA diagnosis of cancer cells and malignant tissues\u003c\/li\u003e\n\u003cli\u003ePresents  innovative methods for quasi-exponential enhancement of RCA-generated  signals, such as nicking enzyme-assisted cascade RCA and RCA coupled  with loop-mediated amplification\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003eAdvance Praise for \u003ci\u003eRolling Circle Amplification (RCA\u003c\/i\u003e):\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003e“This  book provides a badly needed compendium of innovative RCA methods and  applications. It should help further increase the community of  scientists that have employed RCA in research and diagnostic programs.”\u003c\/div\u003e\n\u003cdiv\u003e— Charles Cantor, Professor Emeritus of Biomedical Engineering, Boston University Executive Director, Retrotope Inc. (USA)\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003e“In  this new book Vadim Demidov has assembled an enticing menu of articles  that illustrate the evolution of the RCA field, including improved  protein parts forbuilding superior DNA nanomachines, enhanced  modalities of amplification and detection, diagnostic applications, and  even a sampling of potential therapeutic applications. The reader will  appreciate that while RCA has come of age, there is no lack of exciting  surprises, turns, and twists in the continuing evolution of the  technology.”\u003c\/div\u003e\n\u003cdiv\u003e— Paul Lizardi, Professor of Pathology, Yale  University School of Medicine (retired) Investigator, University of  Granada, Spain, President, PetaOmics, Inc., San Marcos, Texas.\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv\u003e\n\u003cdiv\u003eVadim V. Demidov, Ph.D., is a Senior Analyst in the Biotechnology \u0026amp; Pharmaceuticals Group at Global Prior Art, Inc. (Boston, USA), an intellectual property research and analysis firm. Dr. Demidov received his M.S. degree in Physical and Chemical Engineering from Moscow Institute of Physics and Technology (MIPT, a leading Russian technical university, also known as “the Russian MIT”) and his Ph.D. degree in Biophysics from the Institute of Molecular Genetics of the Russian Academy of Sciences (IMGRAS) and MIPT.\u003c\/div\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv\u003eBefore joining the Global Prior Art company in 2008, he worked for almost 30 years in academia and industry worldwide. Dr. Demidov is well known in the molecular biology and biotechnology field for his innovative studies related to peptide nucleic acid (PNA). He has introduced the use of PNA openers for detection of specific sequences within DNA duplexes under non-denaturing conditions, with some of these applications involving rolling circle amplification (RCA).\u003c\/div\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e17 November 2016\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eSpringer Nature Switzerland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eSpringer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9783319422244\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e176\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Springer Nature Switzerland","offers":[{"title":"Default Title","offer_id":44395550965900,"sku":"9783319422244","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319422244.jpg?v=1780599296","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783319422244","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}