Springer Theses

McDonald, Stacey L.

This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

Details

Published by: Springer

Publication Date: 2016-08-26

Format: Hardcover

ISBN-13: 9783319388779

DOI: 10.1007/978-3-319-38878-6

Dimensions: 235cm x155cm

Pages: 144