{"product_id":"9783319346779","title":"Proteases in Apoptosis: Pathways, Protocols and Translational Advances","description":"\u003ch1\u003eProteases in Apoptosis: Pathways, Protocols and Translational Advances\u003c\/h1\u003e \u003ch2\u003eBose, Kakoli\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book provides a comprehensive overview of the proteases involved in programmed cell death. It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book.\u003c\/p\u003e\u003cp\u003eWhile slowly unravelling the complexities of apoptosis in chapter one,\u003ci\u003e \u003c\/i\u003ethe next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. The last two chapters complete this discussion by describing different laboratory methodologies and therapeutic advances involving apoptotic proteases. Protocols portraying \u003ci\u003ein vitro\u003c\/i\u003e and \u003ci\u003eex vivo\u003c\/i\u003e colorimetric and fluorescence-based enzyme kinetic studies as well as cell death assays are explained in the fifth chapter. Preclinical \u003ci\u003ein vivo\u003c\/i\u003e models and non-invasive imaging in apoptosis to understand the complexities of disease progression and their contribution toward therapeutics is recounted in the last chapter.\u003c\/p\u003e\u003cp\u003eThe book spans topics related to both fundamental and applied biology. It would therefore be equally appealing and informative to scientists working in the field of apoptosis and those who are investigating mechanisms of proteases and enzymes in general. The protocols would certainly benefit both graduate and undergraduate students working in the related fields and provide useful leads for drug design to translational biologists involved in neurodegeneration and cancer research. \u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2016-10-22\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319346779\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-19497-4\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 245\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":47692902269068,"sku":"9783319346779","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319346779.jpg?v=1776701061","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783319346779","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}