{"product_id":"9783034897594","title":"Progress in Inflammation Research","description":"\u003ch1\u003eProgress in Inflammation Research\u003c\/h1\u003e \u003ch2\u003eRedl, H.\u003c\/h2\u003e \u003cp\u003et Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word \"sepsis\" derives from the Greek meaning decay or rottenness. Tradition­ ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin­ ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon­ stration of microorganisms in the circulation has led to a new definition and under­ standing of sepsis, mainly as the systemic response of the host to an often unde­ tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram­ positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap­ ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera­ peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Birkhäuser\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-10-08\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783034897594\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-0348-8755-7\u003c\/p\u003e \u003cp\u003eDimensions: 240cm x170cm\u003c\/p\u003e \u003cp\u003ePages: 372\u003c\/p\u003e ","brand":"Birkhäuser Basel","offers":[{"title":"Default Title","offer_id":44358928007308,"sku":"9783034897594","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783034897594.jpg?v=1773277717","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783034897594","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}