This edited volume examines recent trends towards more global and transnational research within the field of the history of science, technology, and medicine. It focuses on three major themes which are especially important to this shift in perspective: firstly, the analysis of local/global relationships; secondly, the back-and-forth movement across borders involving encounters and exchanges; and thirdly, the significance of historical actors who played a crucial role as go-betweens—especially between Europe and other regions of the world. Distinct in its breadth, this volume offers insights into a range of topics drawn from the history of science, technology, and medicine from approximately 1760 to the present.