{"product_id":"9783032306197","title":"Antiviral Agents against Emerging Viruses","description":"\u003ch3\u003eTopics in Medicinal Chemistry\u003c\/h3\u003e\u003ch1\u003eAntiviral Agents against Emerging Viruses\u003c\/h1\u003e\u003ch3\u003eRoberto Di Santo | Erik de Clercq\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Chemistry \/ Clinical\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eThis book reviews the current landscape of antiviral drug discovery with a strong focus on viral enzymes as therapeutic targets. It presents a timely, mechanism‑driven overview of approved drugs, clinical candidates, and emerging inhibitor classes developed against major human pathogens, including HIV‑1, SARS‑CoV‑2, West Nile virus, Crimean‑Congo hemorrhagic fever virus, and other hemorrhagic fever viruses. By integrating historical perspectives with recent breakthroughs, the volume highlights both the progress achieved and the challenges that remain in antiviral therapeutics.\u003c\/p\u003e\r\n\u003cp\u003eThe chapters cover key viral targets such as integrase, polymerase, helicase, RNase H, and viral proteases, discussing their structure, function, and role in viral replication. Several contributions focus on SARS‑CoV‑2, addressing polymerase, helicase, and protease inhibitors, while others examine antiviral strategies for flaviviruses and emerging hemorrhagic fever viruses that still lack effective treatments. Together, the chapters provide a coherent overview of target‑based antiviral research across diverse virus families.\u003c\/p\u003e\r\n\u003cp\u003eThis book appeals to researchers, advanced students, and professionals in medicinal chemistry, virology, pharmacology, and drug discovery, as well as to clinicians and translational scientists seeking an up‑to‑date reference on antiviral targets and inhibitor development for both established and emerging viral infections.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eErik De Clercq\u003c\/strong\u003e is Emeritus Professor of KU Leuven (Belgium), and has, since 2007 been teaching the course of “Chemistry at the Service of Medicine” at the Faculty of Sciences at the University of South Bohemia (Cěske Budéjovice, Czech Republic) in a joint program with Keppler University (Linz, Austria). He received the Dr. Paul Janssen Award for Biomedical Research in 2010 jointly with Dr. Anthony S. Fauci. He has (co)discovered a number of antiviral drugs currently used in the treatment of HSV (valaciclovir), VZV (brivudin), CMV (cidofovir), HBV [adefovir dipivoxil, tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF)], and HIV infections (TDF, TAF). The combination of TDF with emtricitabine (Truvada) has been approved worldwide for the prophylaxis of HIV infections.\u003c\/p\u003e\r\n\u003cdiv\u003e\r\n\u003cp\u003e\u003cstrong\u003eRoberto Di Santo\u003c\/strong\u003e is a Full Professor of Medicinal Chemistry, School Pharmacy and Medicine, at the “Sapienza” University of Rome, Italy, and Vice-President of the Medicinal Chemistry Division of the Italian Chemical Society. Prof. Di Santo's research is focused primarily on drug design and synthesis of new molecular entities endowed with biological activities. He devoted particular efforts to the discovery of antimicrobial and antitumor agents. Most of his scientific activity is focused on compounds active against HIV targets like integrase, ribonuclease H and polymerase functions of the reverse transcriptase, and protease. he is also the author or co-author of books and 160+ publications and patents. Prof. Di Santo is an active member of EFMC and SCI.\u003c\/p\u003e\r\n\u003cbr\u003e\r\n\u003cdiv\u003e \u003c\/div\u003e\r\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e24 July 2026\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eSpringer Nature Switzerland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eSpringer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9783032306197\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e240\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Springer Nature Switzerland","offers":[{"title":"Default Title","offer_id":50297632096396,"sku":"9783032306197","price":269.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783032306197.jpg?v=1780593331","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783032306197","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}