Poor treatment adherence is widely recognised as the leading cause of uncontrolled chronic disease. Yet poor adherence—and particularly the non-persistence of long-term pharmacological therapies—remains largely under-recognised and underdiagnosed in everyday clinical practice. A growing body of evidence clearly demonstrates that existing approaches are insufficient and that innovative solutions are urgently needed.

These solutions include not only the development of new technologies for the remote and continuous monitoring of adherence, but also a rethinking of care delivery models. Greater engagement of healthcare professionals within a coordinated, team-based care framework is essential, alongside a more active role for patients through shared decision-making and self-management strategies.

This book provides a timely and comprehensive overview of these emerging developments, exploring their practical application in the management of chronic diseases. While particular emphasis is placed on so‑called “silent” conditions—such as hypertension, dyslipidaemia, and diabetes—the discussion also extends to other long-term illnesses, including HIV, heart failure, and respiratory diseases. By integrating scientific evidence, clinical experience, and innovative care models, the book aims to offer clinicians and researchers actionable insights to improve long-term outcomes in chronic disease management.