This book reports on innovations and engineering achievements of industrial relevance, with a special emphasis on developments in mechatronics, control engineering and signal processing. Gathering peer-reviewed papers presented at the 5th International Conference “Innovation in Engineering”, ICIE 2026, held on June 24-26, 2026, in Bucharest, Romania, it covers advances in automated detection and monitoring systems, industrial applications of machine learning and artificial neural networks, and industrial robots and medical devices, among other topics. This second volume of a three-volume set provides engineering researchers and professionals with a timely snapshot of technologies and strategies that should help improve production efficiency, industrial sustainability, and human well-being.