This volume constitutes the proceedings of 10th International Conference on Mining Intelligence and Knowledge Exploration, MIKE 2025, held in Chennai, India, during December 9–13, 2025.

The 63 full papers included in this book were carefully reviewed and selected from 256 submissions. The MIKE conference series continues to provide a premier international forum for researchers, academicians, and industry professionals to exchange ideas, present novel research contributions, and discuss emerging challenges and opportunities in areas such as Artificial Intelligence, Machine Learning, Data Mining, Knowledge Exploration, Natural Language Processing, Computer Vision, Internet of Things, Intelligent Security Systems, Generative AI, and other related domains.