Agentic Medicine brings a transformative approach to healthcare delivery through multimodal AI agents capable of autonomous clinical reasoning, real-time patient monitoring, and adaptive decision-making. This comprehensive textbook presents the PARM (Planning, Action, Reflection, Memory) framework as a unified architecture for developing AI systems that can independently analyze complex medical data, implement therapeutic interventions, and continuously learn from clinical outcomes across diverse healthcare domains.

Designed for clinicians, AI researchers, healthcare administrators, and medical informatics professionals, this work bridges the gap between AI capabilities and real-world medical applications, offering visionary perspectives on autonomous healthcare systems and actionable guidance for the development, validation, and deployment of AI agents that improve patient outcomes while maintaining human oversight and ethical standards.

Dr. Rasit Dinc holds dual doctorate degrees in health sciences and business administration and is a distinguished professor of health sciences. He has conducted  advanced academic research at some of the world’s most prestigious institutions, including Harvard, MIT and Yale, where he gained extensive expertise in his fields. Dr. Dinc serves as the Chairman of the Board at INVAMED, a medical innovation institute globally recognized as a leader in the development and production of innovative medical devices and healthcare solutions. With more than 100 patented medical devices and treatment methods, Dr. Dinc is a leading figure in global healthcare innovation. His research is widely published and frequently cited in international scientific journals, reflecting the strong impact of his work worldwide. He is also a regular speaker at international congresses and symposia, where he shares his research, medical innovations, and insights on health sciences, digital health, and biotechnology. In addition to his scientific and institutional leadership, Dr. Dinc is also the accomplished author of Natural Health Sciences: A Comprehensive Guide (CRC Press), Digital Health: The Impact of Technology on Healthcare and Machine Learning for Healthcare (Troubador Publishing), and Navigating the Business Side of Biomedicine and Biotechnology (Walter de Gruyter).

Nurittin Ardic, MD is a Professor of Clinical Microbiology and Basic Immunology. He works at INVAMED (Ankara, Turkey) as the Medical Director, and works as voluntarily consultant at Med-International UK Health Agency Ltd. (Nuneaton, England). His research focuses on neutrophil extracellular traps (NETs) in cardiovascular diseases, AI applications in healthcare, and translational medicine. Dr. Ardic has published extensively on immunothrombosis, biomarker discovery, and precision medicine, with particular expertise in integrating artificial intelligence methodologies into biomedical research. He also operates a holistic medical practice combining evidence-based medicine with innovative therapeutic approaches.