This textbook serves as a comprehensive English translation of the sixth edition of Fondamenti di Chimica and has been significantly expanded to introduce undergraduate students to the fundamental principles of chemistry. In addition to core topics, it also addresses chemical kinetics, electrochemistry, nuclear and organic chemistry, biochemistry, the chemistry of main-group elements, and transition-metal complexes with their applications in medicinal chemistry. Importantly, the text also provides an extensive discussion of chemistry and the environment, as well as the relevance of symmetry properties in chemistry. Significantly, the contents highlight the connections between chemistry and such fields as medicine, industry, and environmental science. Chapters are so structured to also support use in advanced courses. Through clear writing, detailed illustrations, and solved examples, the authors present the material in an accessible and practical manner. The book fosters problem-solving skills and enhances students’ understanding of the significance of chemistry in daily life and scientific advancement.