{"product_id":"9783032212801","title":"Springer Series in Biophysics: Mechanism Underlying the Parkinson’s Disease and Movement Disorders","description":"\u003ch1\u003eSpringer Series in Biophysics: Mechanism Underlying the Parkinson’s Disease and Movement Disorders\u003c\/h1\u003e \u003ch2\u003eZhang, Jiapu\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-AU\" style=\"color: black;\"\u003eParkinson’s disease (PD), the second most common neurodegenerative disorder in human. The cause of PD is believed to involve genetic factors. At least 6 pathogenic genes have been associated with familial PD. α-Synuclein (αS) is the main component of the Lewy bodies that accumulate in the brains of people with PD. Misfolding of the αS protein has been implicated in the molecular chain of events leading to PD. This book studies wild type (WT) αS proteins and their (8) αS(1-140)-mutants by optimization and Molecular Dynamics (MD). In this book our systematic MD study of a wider range of mutants would provide some answers for genetic factors. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-AU\" style=\"color: black;\"\u003eNumerous bindings of some segments of αS are also MD studied. Some fibrils leaded by aS misfolding are MD studied too.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-AU\" style=\"color: black;\"\u003eThis book is particularly valuable for professionals working in computing roles within computational biochemistry\/biophysics, bioinformatics, etc. It serves as an accessible introduction and is an excellent resource for students.\u003c\/span\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2026-07-09\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783032212801\u003c\/p\u003e \u003cp\u003eDOI: \u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: \u003c\/p\u003e ","brand":"Springer Nature Switzerland","offers":[{"title":"Default Title","offer_id":46265565053068,"sku":"9783032212801","price":179.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783032212801.jpg?v=1776438247","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783032212801","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}