Now in a revised and expanded second edition, this book provides an up-to-date, comprehensive review of donation after circulatory death (DCD) liver transplantation as well as machine perfusion. Since the time of the original publication, the number of DCD liver transplants in the United States and around the world has grown exponentially. Most notably, machine perfusion techniques such as ex-situ machine perfusion and in-situ normothermic regional perfusion (NRP) have allowed for the utilization of organs that previously would not have been usable.

This comprehensive text will act as a resource for programs that are interested in starting or expanding a DCD liver transplant program, covering history, ethics, current techniques and technologies for resuscitaiton, transplantation and storage, international perspectives, and future directions. In particular, the current edition explores in depth the use of normothermic machine perfusion (NMP), normothermic regional perfusion (NRP), and hypothermic oxygenated perfusion (HOPE) techniques and how they can be leveraged to increase the availability and improve the safety and outcomes when using DCD liver grafts. Chapters have been written by a world-class group of leaders in DCD liver transplant, with a target audience including liver transplant surgeons, medical doctors and any other individuals involved in the transplant process. 

Kristopher P. Croome, MD, Department of Transplant, Mayo Clinic Florida, Jacksonville, FL, USA

Gabriel C. Oniscu, MD, FRCS(Ed), Division of Transplantation Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

C. Burcin Taner, MD, Department of Surgery, Transplant Center, Mayo Clinic, Jacksonville, FL, USA