This book constitutes the refereed conference proceedings of the Second Workshop on Artificial Intelligence with and for Learning Sciences - Past, Present, and Future Horizons, WAILS 2025, held in Cagliari, Italy, during December 10-12, 2025.

The 13 full papers and 10 short papers presented in this book were carefully reviewed and selected from 24 submissions. They reflect the methodological and thematic breadth of contemporary research, spanning creativity-oriented and multimodal learning environments powered by artificial intelligence, fairness-aware and trustworthy educational technologies, teacher training, digital literacy, learning analytics, and inclusive and accessible learning ecosystems, among others.