{"product_id":"9783031803956","title":"Recent Results in Cancer Research: Biology, management, and treatment of sporadic and hereditary MTC","description":"\u003ch1\u003eRecent Results in Cancer Research: Biology, management, and treatment of sporadic and hereditary MTC\u003c\/h1\u003e \u003ch2\u003eRaue, Friedhelm; Frank-Raue, Karin\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eAfter 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists.\u003c\/p\u003e\n\u003cp\u003eMedullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective  tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC. \u003c\/p\u003e\n\u003cp\u003eThis book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2025-03-20\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783031803956\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-031-80396-3\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 307\u003c\/p\u003e ","brand":"Springer Nature Switzerland","offers":[{"title":"Default Title","offer_id":45227903385740,"sku":"9783031803956","price":143.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783031803956.jpg?v=1774494896","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783031803956","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}