This book presents the proceedings of the 10th International Conference on Mobile Wireless Middleware, Operating Systems and Applications (MOBILWARE 2021), held virtually in a live stream. The papers included contribute to organized topics of 5G wireless communication, wireless sensor networks, knowledge extraction, instantaneous availability, complex networks, computer vision for mobile application, and mobile support robots. The research presents both theoretically and experimentally based topics. The work particularly benefits researchers, graduate students, and engineers who are interested in related technique improvement ranging from communication middleware and operating systems to networking protocols and applications.