{"product_id":"9783030563189","title":"Progress in Inflammation Research","description":"\u003ch1\u003eProgress in Inflammation Research\u003c\/h1\u003e \u003ch2\u003eRossetti, Carlo; Peri, Francesco\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cdiv\u003e\u003c\/div\u003e\u003cdiv\u003e\n\u003cp\u003eTLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs).\u003cbr\u003e\u003c\/p\u003e\n\n\u003cp\u003eThis volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism\/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade.\u003c\/p\u003e\n\n\u003cp\u003eThe book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer’s diseases,  and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis andneuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4. \u003c\/p\u003e\n\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2020-10-31\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783030563189\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-030-56319-6\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 174\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":44521561260172,"sku":"9783030563189","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783030563189.jpg?v=1773277786","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783030563189","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}