{"product_id":"9783030332488","title":"Advances in Experimental Medicine and Biology: Advances in Microbiology, Infectious Diseases and Public Health Volume 12","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology: Advances in Microbiology, Infectious Diseases and Public Health Volume 12\u003c\/h1\u003e \u003ch2\u003eFedele, Giorgio; Ausiello, Clara Maria\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of \u003ci\u003eB. pertussis\u003c\/i\u003e, while the following chapters focus on the role of \u003ci\u003eB. pertussis\u003c\/i\u003e virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines.\u003c\/p\u003ePertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replacedolder-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death.\u003cp\u003e\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThis book is a valuable resource for researchers and clinicians in the field of medical microbiology, vaccine research and infectious diseases.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2020-01-07\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783030332488\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-030-33249-5\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 170\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":47661518815372,"sku":"9783030332488","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783030332488.jpg?v=1776432553","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783030332488","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}