This book discusses the recent advances in natural computation, fuzzy systems and knowledge discovery. Presenting selected, peer-reviewed papers from the 15th International Conference on Natural Computation, Fuzzy Systems and Knowledge Discovery (ICNC-FSKD 2019), held in Kunming, China, from 20 to 22 July 2019, it is a useful resource for researchers, including professors and graduate students, as well as R&D staff in industry.