{"product_id":"9783030166236","title":"Resistance to Targeted Anti-Cancer Therapeutics","description":"\u003ch1\u003eResistance to Targeted Anti-Cancer Therapeutics\u003c\/h1\u003e \u003ch2\u003eMaccalli, Cristina; Todaro, Matilde; Ferrone, Soldano\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book represents an up-dated summary of the state of the art of the characterization of cancer stem cell\/ cancer initiating cell (CSC\/CIC) properties.  An overview of the definition and biological properties of CSCs\/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs\/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs\/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. \u003c\/p\u003e\n\n\u003cp\u003eThis book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs\/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs\/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2019-06-17\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783030166236\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-030-16624-3\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 256\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":47407042003084,"sku":"9783030166236","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783030166236.jpg?v=1775827255","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783030166236","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}