{"product_id":"9782817804910","title":"mTOR Inhibition for Cancer Therapy: Past, Present and Future","description":"\u003ch1\u003emTOR Inhibition for Cancer Therapy: Past, Present and Future\u003c\/h1\u003e \u003ch2\u003eMita, Monica; Mita, Alain; Rowinsky, Eric K.\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs.  \u003c\/p\u003e\u003cp\u003eOver the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compoundscurrently under evaluation. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2015-12-01\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9782817804910\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-2-8178-0492-7\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 300\u003c\/p\u003e ","brand":"Springer Paris","offers":[{"title":"Default Title","offer_id":47407182807180,"sku":"9782817804910","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9782817804910.jpg?v=1775829051","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9782817804910","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}