{"product_id":"9781617377365","title":"Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy","description":"\u003ch1\u003eTransforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy\u003c\/h1\u003e \u003ch2\u003eJakowlew, Sonia B.; Heldin, C.-H.\u003c\/h2\u003e \u003cp\u003eTransforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim­ ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Humana\u003c\/p\u003e \u003cp\u003ePublication Date: 2010-11-19\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003e ISBN-10: 9781617377365\u003c\/p\u003e \u003cp\u003eISBN-13: 9781617377365\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-59745-293-9\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 786\u003c\/p\u003e ","brand":"Humana","offers":[{"title":"Default Title","offer_id":44317021372556,"sku":"9781617377365","price":252.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781617377365_8b657831-d775-42a7-bb2d-2d415ca62932.jpg?v=1755006353","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781617377365","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}