Cancer Drug Discovery and Development

El-Deiry, Wafik S.

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Details

Published by: Humana

Publication Date: 2010-11-19

Format: Paperback

ISBN-13: 9781617374012

DOI: 10.1385/159259851X

Dimensions: 254cm x178cm

Pages: 374