Methods in Molecular Medicine: Methods and Protocols

Iland, Harry; Hertzberg, Mark; Marlton, Paula

A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.

Details

Published by: Humana

Publication Date: 2020-11-21

Format: Paperback

ISBN-13: 9781607614562

DOI: 10.1385/1597450170

Dimensions: 235cm x155cm

Pages: 307