{"product_id":"9781588299307","title":"Checkpoint Responses in Cancer Therapy","description":"\u003ch3\u003eCancer Drug Discovery and Development\u003c\/h3\u003e\u003ch1\u003eCheckpoint Responses in Cancer Therapy\u003c\/h1\u003e\u003ch3\u003eWei Dai\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Oncology \/ General\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\u003cp\u003eResearch has uncovered molecular surveillance mechanisms called checkpoints that tightly monitor cell-cycle processes. Further research promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. This title summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. The distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis to advances in the identification of chemical compounds capable of inhibiting individual mitotic kinases. The book offers a critical summary of findings for researchers in pharmaceutics, biotechnology, cancer, cell-cycle regulation, signal transduction, and apoptosis.\u003c\/p\u003e\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e06 June 2008\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eHumana Press\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eHumana\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781588299307\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e314\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Humana Press","offers":[{"title":"Default Title","offer_id":51556448895116,"sku":"9781588299307","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781588299307.jpg?v=1784774352","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781588299307","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}