{"product_id":"9781588291998","title":"Molecular Neurosurgery with Targeted Toxins","description":"\u003ch1\u003eMolecular Neurosurgery with Targeted Toxins\u003c\/h1\u003e \u003ch2\u003eWiley, Ronald G.; Lappi, Douglas A.\u003c\/h2\u003e \u003cp\u003ePioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Humana\u003c\/p\u003e \u003cp\u003ePublication Date: 2005-03-22\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9781588291998\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-59259-896-0\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 312\u003c\/p\u003e ","brand":"Humana Press","offers":[{"title":"Default Title","offer_id":50148640456844,"sku":"9781588291998","price":179.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781588291998.jpg?v=1779566739","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781588291998","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}