{"product_id":"9781573318730","title":"Barriers and Channels Formed by Tight Junction Proteins I, Volume 1257","description":"\u003ch3\u003eAnnals of the New York Academy of Sciences\u003c\/h3\u003e\u003ch1\u003eBarriers and Channels Formed by Tight Junction Proteins I, Volume 1257\u003c\/h1\u003e\u003ch3\u003eMichael Fromm | Jörg-Dieter Schulzke\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Cell Biology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eTight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin).  \u003ci\u003eBarriers and Channels Formed by Tight Junction Proteins I\u003c\/i\u003e showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system\u003c\/p\u003e \u003cp\u003eNOTE: \u003ci\u003eAnnals\u003c\/i\u003e volumes are available for sale as individual books or as a journal. For informatio.n on institutional journal subscriptions, please visit \u003ca href=\"http:\/\/ordering.onlinelibrary.wiley.com\/subs.asp?ref=1749-6632\u0026amp;doi=10.111\/(ISSN)1749-6632\"\u003ehttp:\/\/ordering.onlinelibrary.wiley.com\/subs.asp?ref=1749-6632\u0026amp;doi=10.111\/(ISSN)1749-6632\u003c\/a\u003e.\u003c\/p\u003e \u003cp\u003eACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http:\/\/www.nyas.org\/MemberCenter\/Join.aspx for more information about becoming a member.\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003eMichael Fromm is the editor of Barriers and Channels Formed by Tight Junction Proteins I, Volume 1257, published by Wiley. Jörg-Dieter Schulzke is the editor of Barriers and Channels Formed by Tight Junction Proteins I, Volume 1257, published by Wiley. \u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e19 June 2012\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-Blackwell\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781573318730\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003ePaperback \/ softback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e252\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e16.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44310674964620,"sku":"9781573318730","price":121.72,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781573318730_8a54567c-ffbe-4ded-bb79-bb07a283e31a.jpg?v=1780170068","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781573318730","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}