{"product_id":"9781573315500","title":"VIP, PACAP, and Related Peptides From Gene to Therapy, Volume 1070","description":"\u003ch3\u003eAnnals of the New York Academy of Sciences\u003c\/h3\u003e\u003ch1\u003eVIP, PACAP, and Related Peptides\u003c\/h1\u003e\u003ch2\u003eFrom Gene to Therapy, Volume 1070\u003c\/h2\u003e\u003ch3\u003eHubert Vaudry | Marc Laburthe\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Cell Biology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003eThis volume provides an overview on the biochemistry, physiology, and pharmacology of vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), and related peptides. \u003cbr\u003e   \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eVIP and PACAP are undoubtedly among the most fascinating neuropeptides ever identified. They belong to the largest family of regulatory peptides, which comprises several other prominent neuroendocrine peptides including secretin (the first peptide hormone that has been identified), glucagon, and growth hormone-releasing hormone. The structural and physiological relationships of these peptides as well as their receptors provide a unique model for investigating the processes of molecular evolution leading to the diversification of multigene families.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThe primary structures of VIP and PACAP have been remarkably well conserved across vertebrates, suggesting that these peptides must be involved in vital functions throughout the animal kingdom. Indeed, VIP and PACAP appear to be implicated in a large array of physiological processes such as development; growth; endocrine, cardiovascular, respiratory, reproductive and digestive functions; immune responses; and circadian rhythms. There is also clear evidence that VIP and PACAP exert both trophic and antiproliferative effects on normal and tumor cells. The beneficial influence of VIP and PACAP agonists and antagonists in various pathological states including heart failure, ischemia, asthma, impotence, and cancer has motivated the development of novel selective VIP or PACAP ligands that could potentially be used as antihypertensive, neuroprotective, bronchodilatory, vasodilatory, and\/or antiproliferative drugs. The occurrence of multiple VIP\/PACAP receptor subtypes and splice variants that exhibit tissue-specific expression and possess differential affinity for various ligands generates hopes for the development of new therapeutic agents that could act selectively on the desired target cells.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003ci\u003e\u003cb\u003eNOTE:\u003c\/b\u003e Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit\u003c\/i\u003e \u003ca href=\"http:\/\/www.blackwellpublishing.com\/nyas\"\u003e\u003cu\u003e\u003ci\u003ewww.blackwellpublishing.com\/nyas\u003c\/i\u003e\u003c\/u\u003e\u003c\/a\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003e\u003cb\u003eACADEMY MEMBERS\u003c\/b\u003e: Please contact the New York Academy of\u003c\/i\u003e \u003ci\u003eSciences directly to place your order (\u003c\/i\u003e\u003ca href=\"http:\/\/www.nyas.org\/\"\u003e\u003cu\u003e\u003ci\u003ewww.nyas.org\u003c\/i\u003e\u003c\/u\u003e\u003c\/a\u003e\u003ci\u003e). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit\u003c\/i\u003e \u003ca href=\"http:\/\/www.nyas.org\/MemberCenter\/Join.aspx\"\u003e\u003ci\u003ehttp:\/\/www.nyas.org\/MemberCenter\/Join.aspx\u003c\/i\u003e\u003c\/a\u003e \u003ci\u003efor more information about becoming a member.\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003eHubert Vaudry is the editor of VIP, PACAP, and Related Peptides: From Gene to Therapy, Volume 1070, published by Wiley. Marc Laburthe is the editor of VIP, PACAP, and Related Peptides: From Gene to Therapy, Volume 1070, published by Wiley. \u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e14 August 2006\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-Blackwell\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9781573315500\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003ePaperback \/ softback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e500\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e36.8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44310352789644,"sku":"9781573315500","price":164.7,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781573315500.jpg?v=1780283568","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781573315500","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}