{"product_id":"9781493938988","title":"Cancer Drug Discovery and Development","description":"\u003ch1\u003eCancer Drug Discovery and Development\u003c\/h1\u003e \u003ch2\u003eRudek, Michelle A.; Chau, Cindy H.; Figg, William D.; McLeod, Howard L.\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThere are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the \u003ci\u003eHandbook of Anticancer Pharmacokinetics and Pharmacodynamics\u003c\/i\u003e, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK\/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer.\u003c\/p\u003e\u003cp\u003eAuthoritative and up-to-date, \u003ci\u003eHandbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition\u003c\/i\u003e provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eRoad map to anticancer drug development from discovery to NDA submission\u003c\/li\u003e\n\u003cli\u003eDiscussion of molecular targets and preclinical screening\u003c\/li\u003e\n\u003cli\u003eDevelopment and validation of bioanalytical methods\u003c\/li\u003e\n\u003cli\u003eChapters on clinical trial design and phase 0, I, II, III clinical trials\u003c\/li\u003e\n\u003cli\u003ePharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents\u003c\/li\u003e\n\u003cli\u003eReview of the drug development process from both laboratory and clinical perspectives\u003c\/li\u003e\n\u003cli\u003eNew technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Humana\u003c\/p\u003e \u003cp\u003ePublication Date: 2016-08-23\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781493938988\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4614-9135-4\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 836\u003c\/p\u003e ","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":44398676869260,"sku":"9781493938988","price":251.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781493938988.jpg?v=1777986320","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781493938988","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}