{"product_id":"9781489977540","title":"Drug Absorption Studies: In Situ, In Vitro and In Silico Models","description":"\u003ch1\u003eDrug Absorption Studies: In Situ, In Vitro and In Silico Models\u003c\/h1\u003e \u003ch2\u003eEhrhardt, Carsten; Kim, Kwang-Jin\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eIn the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ\/cell\/receptor. These \u003cem\u003ein vitro\u003c\/em\u003e models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex \u003cem\u003ein vivo\u003c\/em\u003e situation, \u003cem\u003ein vitro\u003c\/em\u003e models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eStarting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary \u003cem\u003ein vitro\u003c\/em\u003e techniques for drug absorption studies. In addition, chapters on high-throughput assays, \u003cem\u003ein vitro\u003c\/em\u003e-\u003cem\u003ein vivo\u003c\/em\u003e correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is  available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside. \u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2016-08-23\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781489977540\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-0-387-74901-3\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 696\u003c\/p\u003e ","brand":"Springer","offers":[{"title":"Default Title","offer_id":44398664810636,"sku":"9781489977540","price":198.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781489977540.jpg?v=1755440537","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781489977540","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}