{"product_id":"9781475796872","title":"Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells","description":"\u003ch1\u003eChloride Channels and Carriers in Nerve, Muscle, and Glial Cells\u003c\/h1\u003e \u003ch2\u003eAlvarez-Leefmans, F.J.; Russell, John M.\u003c\/h2\u003e \u003cp\u003eThis is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s assigned Cl- a ther­ modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem­ brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at thermodynamic equilibrium. These two observations were gener­ alized and virtually all cells were thought to have a very high P Cl and a ther­ modynamically passive Cl- transmembrane distribution. These concepts can still be found in some physiology and neuroscience textbooks.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2013-04-27\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781475796872\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4757-9685-8\u003c\/p\u003e \u003cp\u003eDimensions: 254.0cm x178.0cm\u003c\/p\u003e \u003cp\u003ePages: 426.0\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":44408291721356,"sku":"9781475796872","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781475796872.jpg?v=1755791534","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781475796872","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}