{"product_id":"9781475782691","title":"Basic Science for the Cardiologist","description":"\u003ch1\u003eBasic Science for the Cardiologist\u003c\/h1\u003e\u003ch2\u003e\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eContributors:\u003c\/strong\u003e Levy, Bernard I.; Tedgui, Alain\u003c\/p\u003e\u003cp\u003e\u003cem\u003eBiology of the Arterial Wall\u003c\/em\u003e is intended as a general  reference text concerned with the biology of the vascular cells and  the blood vessel wall under physiological and pathological conditions.  One of the major functions of the arteries is to maintain a continuous  blood flow to the organs whatever the pressure conditions, thanks to  the vasomotor tone of the smooth muscle cells. Great advances have  been made over the last decade in the understanding of the endothelial  cells as integrators and transducers of signals originating from the  blood stream. The pluripotent control functions of the endothelial  cells in the vessel wall are now well recognized. A review of  endothelial functions and dysfunctions is presented. \u003cbr\u003e  Cell biology and molecular genetic studies have now identified an  array of molecules elaborated by endothelial cells and vascular smooth  muscle cells and by the blood-borne elements which interact with  artery cells, defending the artery against injury and modulating  evolving abnormal processes. Molecules which induce or inhibit  endothelial and\/or smooth muscle cells are currently under great  scrutiny. Angiogenesis, which plays a major role in tumor growth, but  may also be beneficial as a healing process in muscle ischemia, is  discussed. \u003cbr\u003e  Apoptosis, or programmed cell death, has only recently been recognized  as an essential process in blood vessel modeling and remodeling. An  overview of apoptosis in the vascular system is presented. \u003cbr\u003e  It is increasingly evident that the adjustments of the blood vessel  wall are made in the presence of deforming disease processes such as  hypertension and atherosclerosis. \u003cbr\u003e  The second part of the book is concerned with the blood vessel wall in  disease conditions. Several chapters review the role of the vessel and  vascular cells in inflammation, and vascular remodeling during  arterial hypertension and aging. One chapter is devoted to  atherogenesis, atheroma and plaque instability, followed by the  pathophysiology of post-angioplasty restenosis, which is a crucial  issue in modern interventional cardiology.\u003c\/p\u003e\u003ch3\u003eBook Details\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublisher:\u003c\/strong\u003e Springer\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e 2013-03-24\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Paperback\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eISBN-13:\u003c\/strong\u003e 9781475782691\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePages:\u003c\/strong\u003e 278\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Springer","offers":[{"title":"Default Title","offer_id":44358936068236,"sku":"9781475782691","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781475782691.jpg?v=1768929958","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781475782691","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}