{"product_id":"9781475773422","title":"Advances in Experimental Medicine and Biology: Taurine and Excitable Tissues","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology: Taurine and Excitable Tissues\u003c\/h1\u003e \u003ch2\u003eDella Corte, Laura; Huxtable, Ryan J.; Sgaragli, Giampietro; Tipton, Keith F.\u003c\/h2\u003e \u003cp\u003eMitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the “setpoint” andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca \/2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca \/2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2013-03-12\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781475773422\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/b112581\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 652\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":47977767698572,"sku":"9781475773422","price":197.1,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781475773422.jpg?v=1777374854","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781475773422","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}