{"product_id":"9781461486022","title":"Advances in Experimental Medicine and Biology","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology\u003c\/h1\u003e \u003ch2\u003eBrasier, Allan R.\u003c\/h2\u003e \u003cp\u003eAsthma is a chronic relapsing airways disease that represents a major public health problem\nworldwide. Intermittent exacerbations are provoked by airway mucosal exposure\nto pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing\nthe two most common precipitants. In this setting, inducible signaling pathways\nthe airway mucosa play a central role in the initiation of airway inflammation\nthrough production of antimicrobial peptides (defensins), cytokines, chemokines\nand arachidonic acid metabolites that coordinate the complex processes of\nvascular permeability, cellular recruitment, mucous hyper-secretion, bronchial\nconstriction and tissue remodeling. \nThese signals also are responsible for leukocytic infiltration into the\nsubmucosa, T helper-lymphocyte skewing, and allergic sensitization.\n  \n\nCurrently, it\nis well appreciated that asthma is a heterogeneous in terms of onset,\nexacerbants, severity, and treatment response. \nCurrent asthma classification methods are largely descriptive and focus\non a single aspect or dimension of the disease. \nAn active area of investigation on how to collect, use and visualize multidimensional\nprofiling in asthma.  This book will\noverview multidimensional profiling strategies and visualization approaches for\nphenotyping asthma.  As an outcome, this\nwork will facilitate the understanding of disease etiology, prognosis and\/or\ntherapeutic intervention. ​\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Humana\u003c\/p\u003e \u003cp\u003ePublication Date: 2013-10-27\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461486022\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4614-8603-9\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 354\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":47978084368524,"sku":"9781461486022","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461486022.jpg?v=1777374950","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461486022","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}