{"product_id":"9781461465423","title":"SpringerBriefs in Cancer Research: Immune Escape And Response To Immunotherapy","description":"\u003ch1\u003eSpringerBriefs in Cancer Research: Immune Escape And Response To Immunotherapy\u003c\/h1\u003e \u003ch2\u003eAptsiauri, Natalia; Garcia-Lora, Angel Miguel; Cabrera, Teresa\u003c\/h2\u003e \u003cp\u003eAbnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy.  Precise identification of the mechanism leading to MHC class I defects  will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immunotherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy. ​\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2013-02-22\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461465423\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4614-6543-0\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 51\u003c\/p\u003e ","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":47406425931916,"sku":"9781461465423","price":49.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461465423.jpg?v=1775826322","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461465423","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}