{"product_id":"9781461425243","title":"Cancer Genetics","description":"\u003ch1\u003eCancer Genetics\u003c\/h1\u003e \u003ch2\u003eThomas-Tikhonenko, Andrei\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eOncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-03-07\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461425243\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4419-0711-0\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 480\u003c\/p\u003e ","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":49472028475532,"sku":"9781461425243","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461425243.jpg?v=1777987612","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461425243","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}