{"product_id":"9781461412212","title":"Advances in Experimental Medicine and Biology: Roles in Signaling and Disease Mechanisms","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology: Roles in Signaling and Disease Mechanisms\u003c\/h1\u003e \u003ch2\u003eJasmin, Jean-François; Frank, Philippe; Lisanti, Michael P.\u003c\/h2\u003e \u003cp\u003eCaveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and\/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-01-30\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461412212\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4614-1222-9\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 184\u003c\/p\u003e ","brand":"Springer New York","offers":[{"title":"Default Title","offer_id":47976801140876,"sku":"9781461412212","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461412212.jpg?v=1777374527","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461412212","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}