{"product_id":"9781461380559","title":"Developments in Cardiovascular Medicine","description":"\u003ch1\u003eDevelopments in Cardiovascular Medicine\u003c\/h1\u003e \u003ch2\u003eYellon, Derek M.; Gross, Garrett J.\u003c\/h2\u003e \u003cp\u003eThe ATP-sensitive potassium channel (K\u003csub\u003eATP\u003c\/sub\u003e) was  discovered in 1983. Since then, an enormous amount of research has  been undertaken to characterize it in detail. This volume consolidates  both the current knowledge and most recent advances on the subject,  and its relationship to myocardial protection. To this end, the  editors have assembled investigators at the forefront of ongoing basic  and clinical research to provide scholarly and candid comments  concerning each of the pertinent issues, including: a comprehensive  review of the biology of the channel with respect to the  structure-activity relationship as well as overall chemistry of  the channel; the role of opening this channel and its effect on smooth  muscle (covering both the effects on myocardial stunning and its  ability to protect against myocardial infarction); the relationship of  K\u003csub\u003eATP\u003c\/sub\u003e channel opening and the protection to the myocardium  afforded by the phenomenon of ischemic preconditioning; the  relationship between the K\u003csub\u003eATP\u003c\/sub\u003e channel and electrophysiological  consequences with specific reference to arrhythmogenicity; and the  clinical implications of the use of agents that mimic the opening of  this channel, with reference to its protective nature and its use in  the treatment of angina. \u003cbr\u003e  \u003cem\u003eAudience:\u003c\/em\u003e Clinicians and basic scientists who have a direct  interest in the K\u003csub\u003eATP\u003c\/sub\u003e channel as well as those groups who are  interested in the entire concept of myocardial protection and its  relationship to academic and clinical medicine.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2011-09-27\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461380559\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4613-0453-1\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 214\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46311877738636,"sku":"9781461380559","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461380559.jpg?v=1771513693","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461380559","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}