{"product_id":"9781461372097","title":"Advances in Experimental Medicine and Biology: Basic and Clinical Implications","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology: Basic and Clinical Implications\u003c\/h1\u003e \u003ch2\u003eEhrlich, Yigal H.\u003c\/h2\u003e \u003cp\u003eNumerous studies have proven the biological basis of memory  formation and have begun to identify the biochemical traces and  cellular circuits that are formed by experience, and which participate  int the storage of information in the brain, its retention for long  durations, and its retrieval upon demand. Cells in the nervous system  have the capability of undergoing extremely long-lasting alterations  in response to hormonal, pharmacological, and environmental  stimulations. The mechanisms underlying this neuronal plasticity are  activated by experiential inputs and operate in the process of  learning and the formation of memories in the brain. This volume  presents research areas which have not been highlighted in the past.  In addition to studies on the involement of functional proteins in  neuronal adaptation, this volume presents recent developments on the  critical roles of bioactive lipids and nucleotides in these processes.  In addition to the widely studied role of second messengers, a review  of studies on extracellular phosphorylation systems operating on the  surface of brain neurons is presented.The first section of the volume  presents studies of basic mechanisms operating in a wide range of  adaptive processes. The second section presents recent advances in  investigations that have demonstrated the clinical implications of  this research. These include: state of the art use of transgenic  models in studies of molecular and cellular mechanisms implicated in  familial Alzheimer's disease and Amyotrophic Lateral Sclerosis;  studies of specific proteins implicated in Alzheimer's disease,  including an adapter that binds to the beta-amyloid precurser protein  (beta-APP) and the microtubular protein Tau and its membrane-bound  counterpart. The advantages of using cell culture models for  elucidating the causes of neuronal degeneration and for identifying  mechanisms of neuroprotection are also presented among the chapters in  the section on clinical implications.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-09-27\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461372097\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-4869-0\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 229\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":47977014132876,"sku":"9781461372097","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461372097.jpg?v=1777374605","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461372097","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}