{"product_id":"9781461369554","title":"Developments in Molecular and Cellular Biochemistry","description":"\u003ch1\u003eDevelopments in Molecular and Cellular Biochemistry\u003c\/h1\u003e \u003ch2\u003eRupp, Heinz; Maisch, Bernhard\u003c\/h2\u003e \u003cp\u003eThe special issue of \u003cem\u003eMolecular and Cellular Biochemistry\u003c\/em\u003e  focuses on `Control of Gene Expression by Catecholamines and the  Renin-Angiotensin System' in health and disease. In recent years,  great progress has been made in the understanding of catecholamine and  angiotensin II modulated gene expression. There is also increasing  evidence that catecholamine and angiotensin II induced cellular injury  not solely arises from classical pathways but also from a perturbed  gene expression. \u003cbr\u003e  Taking into account that catecholamines and angiotensin II are vital  for a balanced gene expression of many cells, the intriguing  possibility arises that various disease are initiated or aggravated by  such an imbalance. Catecholamine and angiotensin II influences can be  in excess arising from, for example, hypercaloric food intake or  psychosocial stress. During early progression of heart failure,  sympathetic activity and angiotensin II influences also become  increased. Due to beta-adrenergic receptor downregulation, depressed  catecholamine influences are expected in the final stage of heart  failure. An imbalanced influence of catecholamines and angiotensin II  on gene expression leads to disordered molecular structures of the  cell and an impaired cell function. \u003cbr\u003e  This focused issue is organized into chapters concentrating on  catecholamines, angiotensin II, and the interaction between  catecholamines and angiotensin II. Basic biochemical processes are  covered in detail and the potential of these pathways for explaining  chronic diseases associated with excess catecholamine and angiotensin  II influences should become apparent. It is hoped that this focussed  issue triggers novel research into the development of drugs that are  targeted at diseases characterized by an imbalanced gene expression  involving catecholamines and angiotensin II.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-10-10\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461369554\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-4351-0\u003c\/p\u003e \u003cp\u003eDimensions: 280cm x210cm\u003c\/p\u003e \u003cp\u003ePages: 239\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":44359242514572,"sku":"9781461369554","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461369554.jpg?v=1770785800","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461369554","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}