{"product_id":"9781461369165","title":"Advances in Experimental Medicine and Biology","description":"\u003ch1\u003eAdvances in Experimental Medicine and Biology\u003c\/h1\u003e \u003ch2\u003eGranzier, H.L.; Pollack, Gerald H.\u003c\/h2\u003e \u003cp\u003eElastic filaments refer mainly to titin, the largest of all  known proteins. Titin was discovered initially in muscle cells, where  it interconnects the thick filament with the Z-line. Titin forms a  molecular spring that is responsible for maintaining the structural  integrity of contracting muscle, ensuring efficient muscle  contraction. More recently, it has become clear that titin is not  restricted to muscle cells alone. For example, titin is found in  chromosomes of neurons and also in blood platelets. This topic is fast  becoming a focal point for research in understanding viscoelastic  properties at the molecular, cellular, and tissue levels. In titin may  lie a generic basis for biological viscoelasticity. It has become  clear that titin may hold the key to certain clinical anomalies. For  example, it is clear that titin-based ventricular stiffness is  modulated by calcium and that titin is responsible for the altered  stiffness in cardiomyopathies. It is also clear from evidence from a  group of Finnish families that titin mutations may underlie some  muscular dystrophies and that with other mutations chromatids fail to  separate during mitosis. Thus, it is clear that this protein will have  important clinical implications stemming from its biomechanical role.  One aspect of this field is the bringing together of bioengineers with  clinical researchers and biologists. Genetic and biochemical aspects  of titin-related proteins are being studied together with front-line  engineering approaches designed to measure the mechanics of titin  either in small aggregates or in single molecules.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-11-01\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461369165\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-4267-4\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 425\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":44358959956108,"sku":"9781461369165","price":49.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461369165.jpg?v=1775708119","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461369165","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}