{"product_id":"9781461356172","title":"Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control: Insights for Drug Discovery","description":"\u003ch1\u003eLeukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control: Insights for Drug Discovery\u003c\/h1\u003e \u003ch2\u003eCollins, Tucker\u003c\/h2\u003e \u003cp\u003eThe localized attachment of circulating leukocytes to  endothelium has been recognized as the cellular hallmark of the  inflammatory response. This adhesive interaction, a necessary  antecedent to the emigration of leukocytes from the blood into the  tissues, is mediated by vascular adhesion molecules. \u003cem\u003eLeukocyte  Recruitment, Endothelial Cell Adhesion\u003c\/em\u003e \u003cem\u003eMolecules and  Transcriptional Control: Insights for Drug Discovery\u003c\/em\u003e outlines some  of the cellular and molecular mechanisms of inflammation with  contributions from top researchers.\u003cbr\u003e  This volume provides an overview of three of these endothelial  adhesion molecules, as examples of key mediators of leukocyte  recruitment. It reviews the structure and regulation of these cell  surface proteins and focus on the rapidly expanding field of  transcriptional regulation of these inducible proteins, and closes  with a discussion of drug discovery possibilities that target the  regulation of leukocyte recruitment. \u003cbr\u003e  This book will be of interest for any researchers, in academia or  industry, looking for an overview of leukocyte recruitment or novel  approaches to drug discovery.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-11-05\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003e ISBN-10: 9781461356172\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461356172\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4615-1565-4\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 327\u003c\/p\u003e ","brand":"Springer","offers":[{"title":"Default Title","offer_id":44340563181708,"sku":"9781461356172","price":153.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461356172_5ec8c679-2be6-4b46-8cb5-eb384e1537a5.jpg?v=1755044640","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461356172","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}