{"product_id":"9781461284352","title":"Cytokines and Growth Factors in Blood Transfusion: Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord Nederland","description":"\u003ch1\u003eCytokines and Growth Factors in Blood Transfusion: Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord Nederland\u003c\/h1\u003e \u003ch2\u003eSmit Sibinga, C.Th.; Das, P.C.; Löwenberg, B.\u003c\/h2\u003e \u003cp\u003eCytokines are cellular growth factors which also provide  communication between cells and their milieu. This clearly is an  exciting area in modern medicine that will have significant impact on  various facets of transfusion. Erythropoietin therapy stimulates red  cell production while thrombopoietin seems to positively affect  megakaryopoiesis and can be an added armamentarium for the  thrombocytopenic patient. \u003cbr\u003e  Using haematnopoietic growth factors, stem cells could be mobilized  early to the peripheral blood for collection and subsequent  transplantation into haemato-oncology patients instead of bone marrow  transplantation. Using a cocktail of cytokines in cell culture, stem  cells could be expanded and selected for therapy. Cytokines and growth  factors can even be modified, which may lead to successful gene  therapy in malignancies, including solid tumour vaccines. However, the  presence of cytokines in certain blood products could have biological  effects following transfusion, although its clinical relevance needs  to be ascertained. There is much potential for the use of cytokines in  the treatment of infections. Early diagnostic methods are now  available to monitor their levels and relevance. It is likely that  cytokines will increasingly play a role in therapy and could develop  our fundamental knowledge about the development of T-cells. An ethical  dilemma remains, however, regarding the use of cytokines in healthy  donors for harvesting suitable specific cells. Longer clinical  observation will be necessary to gather the necessary information.  \u003cbr\u003e  Cytokines and growth factors in blood transfusion was the theme of the  21st International Symposium in Blood Transfusion, where twenty  clinicians and scientists, experts in their own fields, were invited  to update the above information. Their findings are presented in four  sections in this volume: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eFundamental aspects  - cytokines in development of T-cells, growth factors in  haematopoiesis, growth factor receptors and signal transduction,  cytokine response in platelet and whole blood transfusions.  \u003c\/li\u003e  \u003cli\u003eFunction, production and diagnosis \u0026amp;endash; laboratory  diagnostics of cytokines and growth factors, cytokines in blood  components, cytokines and growth factors in cell expansions, cytokines  for genetic modification towards gene therapy, progenitor cells from  healthy donors. \u003c\/li\u003e  \u003cli\u003eApplication in clinical medicine \u0026amp;endash;  clinical relevance of cytokines in transfusion products, cytokines and  growth factors in solid tumours, gene therapy in malignancies, vaccine  strategies inducing T-cell immunity against tumours, cytokines in the  treatment of infections, thrombopoietin and megakaryopoiesis.  \u003c\/li\u003e  \u003cli\u003eFuture potential use in transfusion medicine \u0026amp;endash;  erythropoietin, immunotherapy, ethical aspects of the use of cytokines  and growth factors in donors, potential of cytokines and growth  factors in transfusion medicine. \u003c\/li\u003e  \u003c\/ul\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2011-09-17\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9781461284352\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4613-1137-9\u003c\/p\u003e \u003cp\u003eDimensions: 240.0cm x160.0cm\u003c\/p\u003e \u003cp\u003ePages: 206.0\u003c\/p\u003e ","brand":"Springer US","offers":[{"title":"Default Title","offer_id":44358994493580,"sku":"9781461284352","price":161.1,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781461284352_8a3d5eb2-e6e2-4877-bf03-dba2cef9e0db.jpg?v=1765470859","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781461284352","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}