Hughes Syndrome: Highways and Byways is a handy and easy-to-read guide to the main features of Hughes syndrome. There has been worldwide interest in this 'new' syndrome (first described in 1983). A clotting tendency which can potentially affect any organ in the body, it is:

*         responsible for 1 in 5 recurrent miscarriages (now successfully treated with aspirin and heparin)

*         responsible for 1 in 5 young (under 45) strokes

*         a major cause of early heart attacks

*         responsible for 1 in 5 deep vein thromboses

*         an important cause of migraine.

Hughes Syndrome: Highways and Byways is a valuable resource for professionals with an interest in the subject, as well as general practitioners and patients.

Graham Hughes, MD, FRCP The London Lupus Centre London Bridge Hospital, London UK

Munther Khamashta, MD, FRCP, PhD Graham Hughes Lupus Research Laboratory King's College London, UK