{"product_id":"9781447142997","title":"Ankylosing spondylitis and Klebsiella","description":"\u003ch1\u003eAnkylosing spondylitis and Klebsiella\u003c\/h1\u003e \u003ch2\u003eEbringer, Alan\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003ci\u003eAnkylosing spondylitis and Klebsiella \u003c\/i\u003eis a comprehensive and informative text on the cause of Ankylosing spondylitis. Ankylosing spondylitis\u003ci\u003e (\u003c\/i\u003eAS) is a condition which affects 20 million people worldwide and is likely caused or initiated by a bowel infection from \u003ci\u003eKlebsiella \u003c\/i\u003ebacteria.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eWhen a patient is infected by \u003ci\u003eKlebsiella \u003c\/i\u003ebacteria, his or her immune system will make antibodies against all the antigens or molecules found in the microbe. Because some of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will attack not only the bacteria but also the self tissues such as the joints and the cells having the same HLA molecules, which is how the disease AS starts.  This is the concept of molecular similarity or “molecular mimicry” which previously has been found to work in two other autoimmune diseases; rheumatic fever and rheumatoid arthritis. \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThe first paper on this subject was published in 1976 and sincethen\u003cb\u003e \u003c\/b\u003eover 100 papers on rheumatological topics have been published, from Prof Ebringer’s group, at the Division of Life Sciences, King’s College in London, UK. \u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThe relevant information from these papers is extracted and presented in this book format making it accessible to health professionals, research institutions, pharmaceutical companies and universities and the general public. \u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-11-06\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9781447142997\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-1-4471-4300-0\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 256\u003c\/p\u003e ","brand":"Springer London","offers":[{"title":"Default Title","offer_id":50149230805132,"sku":"9781447142997","price":179.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9781447142997.jpg?v=1779573410","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9781447142997","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}